A Cleaner Way to Study Membrane Protein Dynamics

ALOMONE NEWS

Membrane proteins are a challenge to track in live cells – big fluorescent tags can throw off their function, and antibodies can crosslink or mislabel them. If you’ve been struggling with these issues, the bungarotoxin binding site (BBS) might be the answer.

BBS tagging uses a tiny 13-amino acid sequence that binds with nanomolar precision to alpha-bungarotoxin. It’s minimally invasive, highly specific, and works across a range of membrane proteins, from AMPA and GABAA to Piezo1.

The result is real-time, high-resolution imaging without artificial clustering or functional disruption.

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