All Posts

In a market where dNTPs and NTPs are readily available, few suppliers go beyond the basics to guarantee truly exceptional quality. At Jena Bioscience, we don't just meet basic market standards, we exceed them. What sets us apart? Purity beyond the standard: minimum purity of 99.0 %, free of human or bacterial DNA, and free of DNases, RNases or proteases, and inhibitory ions and contaminants that interfere with PCR performance. Proven functionality: Clear results even in PC

In 2025, some of the most decisive biology happened at the membrane. Receptors, ion channels, and cytoskeletal structures moved beyond signal relay to determine invasion, inflammation, extrusion, and even food choice. Our new blog recaps some of the year’s most influential papers, including: Drugging a buried helix to block metastasis Targeting the p75NTR transmembrane domain shut down NGF-fascin coupling and reduced melanoma lung invasion. Ion channels steering inflammation

Santa Cruz Santa Cruz Biotechnology provides a curated selection of protein modulator chemicals that support researchers across the life sciences. Find a comprehensive portfolio of chemical modulators designed to activate or inhibit protein targets in key research areas, including signal transduction, epigenetics, immunology, & cancer biology. Popular Modulator Raf Kinase Inhibitor V (CAS 918505-84-7) Alternate Names: PLX-4720 Application: Raf Kinase Inhibitor V is an inhibit

For researchers working with long IVT mRNA, self-amplifying RNA (saRNA) constructs, or long single-stranded RNA, the stability and sizing reliability of RNA ladders often become critical factors in experimental interpretation. Our Ultra High Range RNA Ladder is designed to deliver the consistency and clarity needed for accurate sizing of long RNA species. Key Features Single-stranded RNA (ssRNA) generated by in vitro transcription (IVT) Includes 6k / 9k / 12k / 15k RNA fragme

Most people think hearing is about volume – how loud a sound is or whether it gets through. But new research shows that what really matters is timing. In this installment of our Senses series, we look at new work showing how: Brainstem neurons rely on voltage-gated potassium channel 4 (Kv4) to preserve sub-millisecond spike fidelity. Efferent inhibition delays responses to protect against noise overload. Gene therapy can restore structural timing cues in the cochlea. Loss of

Smell is often written off as a minor sense – but biologically, it’s a direct and highly sensitive portal into the nervous system. In this new instalment of our Senses series, we look at four recent studies that show how olfaction flags early neuroinflammation through A1R upregulation, adapts to mechanical stress via CNGA2-positive neurons, responds to chemical cooling through TRPM8, and encodes memory with shifting GluN2A/GluN2B NMDA receptor composition. The nose is doing

Quick guide to choosing recombinant protein & growth factors for stem cells, immune cells, and organoid cultures. Recombinant protein and growth factors are essential for cell growth, differentiation, and functional activation. Because each protein varies in source, activity, and stability, choosing the right one is key to achieving reliable, reproducible results. This guide highlights recommended cytokines for different cell types—helping you select the best match for your e

Taste recalibrates every day. In this instalment of our Senses series, we look at how diet, local feedback, and brain-immune crosstalk reshape what flavors mean to the body. Sugar rewrites sensitivity: high-sucrose diets reduce sweet nerve responses and the number of PLCβ2-positive taste cells – all reversible once sugar is removed. Taste glia fine-tune sweetness: type I cells use P2RY2 signaling to dampen prolonged sweet responses, preventing signal overload during sustained

RFP Self-Amplifying RNA (saRNA) delivers bright, long-lasting red fluorescence (~583 nm) for live-cell imaging, gene expression studies, and protein localization. Its self-amplifying design enables stronger, sustained expression at lower doses than traditional mRNA. Croyez’s RFP saRNA is IVT-produced and optimized with Cap1 and a 3' poly(A) tail to enhance stability and translation, ensuring performance comparable to mature cellular mRNA. 24-Day RFP Expression Experience long

C-Reactive Protein — a key acute-phase reactant produced by the liver — serves as a sensitive biomarker for inflammation, infection, and tissue damage.When the body faces infection or injury, CRP levels rise rapidly, helping activate complement and enhance phagocytosis — the body’s way of clearing pathogens and damaged cells. Why CRP Matters Bacterial vs. viral infections: CRP increases sharply in bacterial infections but only slightly in viral ones — aiding in infection diff

Santa Cruz Santa Cruz Biotechnology provides a curated selection of protein modulator chemicals that support researchers across the life sciences. Find a comprehensive portfolio of chemical modulators designed to activate or inhibit protein targets in key research areas, including signal transduction, epigenetics, immunology, & cancer biology. Scrivici per info Contattaci

JENA BIOTECH NEWS Bacteria have developed countless ways to defend themselves against viral attacks. In this Nature paper, Sullivan and colleagues discovered a completely new mechanism: the Panoptes system [1] . In Greek mythology, Argus Panoptes was the “all-seeing guardian”, a giant with a hundred eyes who never fully slept, because some of his eyes were always open. Panoptes literally means “the all-seeing” and that’s exactly what the system does - it watches constantly f

Don't leave screening to chance - screen with strategy: discover the JBScreen JCSG++ crystallization screen family! Learn more...

dTomato Self-Amplifying RNA encodes a bright red fluorescent protein, emitting light at 581 nm. It is ideal for tracking gene expression, protein localization, and live cell imaging. As a self-amplifying RNA, it offers enhanced, prolonged expression with lower doses, making it efficient for extended studies. Croyez’s tdTomato saRNA was generated through in vitro transcription, and these mRNAs are then fortified at their 5' end by modified nucleotide capping, known as Cap1. To

From neuronal growth and glucose transport to appetite regulation and energy balance, our newest reagents expand the toolkit for studying neural and metabolic pathways. Anti-Plexin-B1 (extracellular) Antibody (#APR-088) An extracellular antibody for detecting native cell-surface Plexin-B1 in immunostaining, flow cytometry, and biochemical assays, supporting studies of neuronal guidance and signaling. Anti-Human GLUT3 (extracellular)-PE Antibody (#AGT-043-PE) A PE-conjugated e

ALOMONE LABS NEWS A new study in Nature Cell Biology revealed that neural stem cells (NSCs) aren’t limited to the brain and spinal cord. Researchers identified multipotent peripheral NSCs (pNSCs) in the lung, tail, and dorsal root ganglia that self-renew, express canonical markers, and differentiate into neurons and glia – without reprogramming. Remarkably, these neurons are electrically active, showing voltage-gated sodium and potassium currents, with the sodium current full

CROYEZ NEWS Croyez provides a comprehensive portfolio of high-purity, ready-to-use gene-editing mRNAs—including ABEmax, dCas9-KRAB, and hSpCas9.Each transcript is in vitro transcribed, precisely purified, and available in both unmodified and m¹Ψ-modified formats to enhance expression stability and minimize immunogenicity.By offering fully optimized, ready-to-use mRNAs, Croyez helps researchers eliminate the complexity of in-house transcription and purification—accelerating yo

Discover how tCOTP is transforming RNA research and opens new possibilities for tracking mRNA delivery and function. Learn more: https://www.jenabioscience.com/about-us/news-blog/3685-tcotp-enhancing-mrna-studies-with-native-like-fluorescent-labels Per info Contattaci

ALOMONE LABS NEWS From our labs to yours - We captured NGF trafficking in live cells. Using our exclusive mouse NGF 2.5S-ATTO Fluor-647N (#N-240-FRN), scientists captured time-lapse images showing NGF binding to PC-12 neuronal model cell membranes followed by transport into the cytoplasm – a process previously studied in fixed cells. This live-cell experiment confirms the full biological activity of NGF-ATTO Fluor-647N while opening new possibilities for dynamic neurotrophin

ALOMONE NEWS If you're using human induced pluripotent stem cell (hiPSC)-derived microglia to study brain disorders, you know how slow and finicky they can be. A recent study validated a faster route and generated induced microglia (iMGs) from peripheral blood monocytes in under 2 weeks. These iMGs show the expected morphology, express microglia-specific markers like TMEM119 as well as P2RY12 [detected using Alomone’s Anti-P2Y12 Receptor (extracellular) antibody (#APR-020) ]