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Don't leave screening to chance - screen with strategy: discover the JBScreen JCSG++ crystallization screen family! Learn more...

dTomato Self-Amplifying RNA encodes a bright red fluorescent protein, emitting light at 581 nm. It is ideal for tracking gene expression, protein localization, and live cell imaging. As a self-amplifying RNA, it offers enhanced, prolonged expression with lower doses, making it efficient for extended studies. Croyez’s tdTomato saRNA was generated through in vitro transcription, and these mRNAs are then fortified at their 5' end by modified nucleotide capping, known as Cap1. To

From neuronal growth and glucose transport to appetite regulation and energy balance, our newest reagents expand the toolkit for studying neural and metabolic pathways. Anti-Plexin-B1 (extracellular) Antibody (#APR-088) An extracellular antibody for detecting native cell-surface Plexin-B1 in immunostaining, flow cytometry, and biochemical assays, supporting studies of neuronal guidance and signaling. Anti-Human GLUT3 (extracellular)-PE Antibody (#AGT-043-PE) A PE-conjugated e

ALOMONE LABS NEWS A new study in Nature Cell Biology revealed that neural stem cells (NSCs) aren’t limited to the brain and spinal cord. Researchers identified multipotent peripheral NSCs (pNSCs) in the lung, tail, and dorsal root ganglia that self-renew, express canonical markers, and differentiate into neurons and glia – without reprogramming. Remarkably, these neurons are electrically active, showing voltage-gated sodium and potassium currents, with the sodium current full

CROYEZ NEWS Croyez provides a comprehensive portfolio of high-purity, ready-to-use gene-editing mRNAs—including ABEmax, dCas9-KRAB, and hSpCas9.Each transcript is in vitro transcribed, precisely purified, and available in both unmodified and m¹Ψ-modified formats to enhance expression stability and minimize immunogenicity.By offering fully optimized, ready-to-use mRNAs, Croyez helps researchers eliminate the complexity of in-house transcription and purification—accelerating yo

Discover how tCOTP is transforming RNA research and opens new possibilities for tracking mRNA delivery and function. Learn more: https://www.jenabioscience.com/about-us/news-blog/3685-tcotp-enhancing-mrna-studies-with-native-like-fluorescent-labels Per info Contattaci

ALOMONE LABS NEWS From our labs to yours - We captured NGF trafficking in live cells. Using our exclusive mouse NGF 2.5S-ATTO Fluor-647N (#N-240-FRN), scientists captured time-lapse images showing NGF binding to PC-12 neuronal model cell membranes followed by transport into the cytoplasm – a process previously studied in fixed cells. This live-cell experiment confirms the full biological activity of NGF-ATTO Fluor-647N while opening new possibilities for dynamic neurotrophin

ALOMONE NEWS If you're using human induced pluripotent stem cell (hiPSC)-derived microglia to study brain disorders, you know how slow and finicky they can be. A recent study validated a faster route and generated induced microglia (iMGs) from peripheral blood monocytes in under 2 weeks. These iMGs show the expected morphology, express microglia-specific markers like TMEM119 as well as P2RY12 [detected using Alomone’s Anti-P2Y12 Receptor (extracellular) antibody (#APR-020) ]

CROYEZ NEWS 💡 Today, I’d love to share one of our most trusted RNA markers — the CROYEZ 9K RNA Ladder. It provides stable, clear band visibility from 6K to 12K, no matter the loading concentration. This ladder contains eight single-stranded RNAs (0.2–9 kb) transcribed in vitro from linear DNA templates, offering a consistent size reference for ssRNA or mRNA analysis on native agarose gels. 🧪 Applications mRNA Research: Accurate size verification for therapeutic constructs s

Once overlooked for lacking ligands, several orphan GPCRs are now under active investigation as disease-modifying targets in Alzheimer’s, Parkinson’s, Huntington’s, and multiple sclerosis (MS). Cryo-EM structures and knockout phenotypes have shifted the narrative from transcriptomic curiosity to therapeutic relevance. In this blog, we highlight four key receptors — GPR17, GPR37, GPR52, and GPR88 — and the antibodies available to study them. Anti-GPR17 Antibody (#AGR-048) Anti

Croyez simplifies the complex chemical conjugation process into three easy steps — mix, incubate, and complete — enabling faster, more stable, and highly efficient HRP labeling. The kit achieves high-activity HRP conjugation in a short time, ensuring both enzyme activity and labeling stability, and is ideal for ELISA, Western blot, and immunohistochemistry (IHC) applications. Per info Contattaci

ALOMONE LABS NEWS Inflammation sits at the crossroads of metabolism, immunity, and signaling — and these three molecules illustrate how different protein classes converge to shape immune responses. GPR142, a tryptophan-sensing orphan GPCR primarily known for metabolic regulation, has recently been linked to inflammation. GPR142 is upregulated by proinflammatory cytokines [TNF-α, interleukin (IL)-6, and IL-1β], suggesting a role in amplifying immune or metabolic responses in g

JENA BIOSCIENCE NEWS From crude extract to quantitative analysis in record time? Possible with our Direct qPCR or RT-qPCR Master mixes: your solution to save time and money. Now with a new recipe and easier shipping! Learn more...

Introducing our latest Multiplex qPCR Mix featuring a highly sensitive Hot Start Polymerase in a ready-to-use mixture with improved robustness towards qPCR inhibitors. Make it count and analyse 4 or more targets in one single run. Read more...

Benefit from our fast delivery from stock : Accutase®, the proven alternative to trypsin and collagenase, is available to you immediately in 100 ml and 500 ml bottles. Your benefits at a glance:     Gentle and efficient cell detachment for minimal cell damage     Easy to use application without neutralization steps     Lower contamination risk free from mammalian and bacterial components     Ready to use solution Rely on our efficient supply chain and benefit from prompt

CROYEZ NEWS CROYEZ provides complete RNA QC solutions, from precise RNA ladders (6K–12K) to dual ELISA kits for T7 RNA Polymerase and dsRNA detection.Ensure accurate sizing, impurity control, and consistent quality across every stage of your mRNA workflow. Per info Contattaci

ALOMONE LABS NEWS GLP-1R agonists like Ozempic act on more than just pancreatic tissue. Immune cells also express GLP-1R, but most antibodies fail to detect it. Our anti-GLP-1R antibodies include: Anti-GLP1R (extracellular)-FITC Antibody (#AGR-021-F) Anti-GLP1R (extracellular)-PE Antibody (#AGR-021-PE) Both are among the few cell-surface-binding antibodies validated for flow cytometry and immune studies. Want to discover why cell surface-specific detection is essential for fl

ALOMONE LABS NEWS From glial activation to synaptic remodeling, here’s what antibody detection actually reveals about neurological disease. Antibody-based protein markers remain a fundamental tool in both research and diagnostics for neurological disorders. But the list of available targets keeps growing – and not all are equally reliable, interpretable, or accessible across sample types. You’ll find examples supported by validated Alomone Labs antibodies, including: Anti-GFA

JENA BIOSCIENCE NEWS In a recent Cell paper[1], Glaser, Uhlmann and colleagues show that the replication machinery (replisome) can physically pass through the ring-shaped cohesin complex during DNA replication. We are honored that various nucleotide reagents from Jena Bioscience contributed to the success of this ambitious group of scientists, helping them to truly advance in the field of replication & chromatin research. Using reconstituted biochemical systems and single-mol

SANTA CRUZ NEWS At Santa Cruz Biotechnology, we offer a curated selection of protein modulator chemicals that support researchers across the life sciences. Whether you're investigating signal transduction, immune response, cancer pathways, or epigenetic mechanisms, our modulators are designed for performance & reproducibility. POPULAR MODULATOR Raf Kinase Inhibitor V (CAS 918505-84-7) Alternate Names: PLX-4720 Application: Raf Kinase Inhibitor V is an inhibitor of Raf kinase