ALOMONE NEWS

In 2025, some of the most decisive biology happened at the membrane. Receptors, ion channels, and cytoskeletal structures moved beyond signal relay to determine invasion, inflammation, extrusion, and even food choice. Our new blog recaps some of the year’s most influential papers, including: Drugging a buried helix to block metastasis Targeting the p75NTR transmembrane domain shut down NGF-fascin coupling and reduced melanoma lung invasion. Ion channels steering inflammation

Most people think hearing is about volume – how loud a sound is or whether it gets through. But new research shows that what really matters is timing. In this installment of our Senses series, we look at new work showing how: Brainstem neurons rely on voltage-gated potassium channel 4 (Kv4) to preserve sub-millisecond spike fidelity. Efferent inhibition delays responses to protect against noise overload. Gene therapy can restore structural timing cues in the cochlea. Loss of

Smell is often written off as a minor sense – but biologically, it’s a direct and highly sensitive portal into the nervous system. In this new instalment of our Senses series, we look at four recent studies that show how olfaction flags early neuroinflammation through A1R upregulation, adapts to mechanical stress via CNGA2-positive neurons, responds to chemical cooling through TRPM8, and encodes memory with shifting GluN2A/GluN2B NMDA receptor composition. The nose is doing

From neuronal growth and glucose transport to appetite regulation and energy balance, our newest reagents expand the toolkit for studying neural and metabolic pathways. Anti-Plexin-B1 (extracellular) Antibody (#APR-088) An extracellular antibody for detecting native cell-surface Plexin-B1 in immunostaining, flow cytometry, and biochemical assays, supporting studies of neuronal guidance and signaling. Anti-Human GLUT3 (extracellular)-PE Antibody (#AGT-043-PE) A PE-conjugated e

ALOMONE LABS NEWS A new study in Nature Cell Biology revealed that neural stem cells (NSCs) aren’t limited to the brain and spinal cord. Researchers identified multipotent peripheral NSCs (pNSCs) in the lung, tail, and dorsal root ganglia that self-renew, express canonical markers, and differentiate into neurons and glia – without reprogramming. Remarkably, these neurons are electrically active, showing voltage-gated sodium and potassium currents, with the sodium current full

ALOMONE NEWS If you're using human induced pluripotent stem cell (hiPSC)-derived microglia to study brain disorders, you know how slow and finicky they can be. A recent study validated a faster route and generated induced microglia (iMGs) from peripheral blood monocytes in under 2 weeks. These iMGs show the expected morphology, express microglia-specific markers like TMEM119 as well as P2RY12 [detected using Alomone’s Anti-P2Y12 Receptor (extracellular) antibody (#APR-020) ]

Once overlooked for lacking ligands, several orphan GPCRs are now under active investigation as disease-modifying targets in Alzheimer’s, Parkinson’s, Huntington’s, and multiple sclerosis (MS). Cryo-EM structures and knockout phenotypes have shifted the narrative from transcriptomic curiosity to therapeutic relevance. In this blog, we highlight four key receptors — GPR17, GPR37, GPR52, and GPR88 — and the antibodies available to study them. Anti-GPR17 Antibody (#AGR-048) Anti

ALOMONE LABS NEWS Inflammation sits at the crossroads of metabolism, immunity, and signaling — and these three molecules illustrate how different protein classes converge to shape immune responses. GPR142, a tryptophan-sensing orphan GPCR primarily known for metabolic regulation, has recently been linked to inflammation. GPR142 is upregulated by proinflammatory cytokines [TNF-α, interleukin (IL)-6, and IL-1β], suggesting a role in amplifying immune or metabolic responses in g

ALOMONE LABS NEWS GLP-1R agonists like Ozempic act on more than just pancreatic tissue. Immune cells also express GLP-1R, but most antibodies fail to detect it. Our anti-GLP-1R antibodies include: Anti-GLP1R (extracellular)-FITC Antibody (#AGR-021-F) Anti-GLP1R (extracellular)-PE Antibody (#AGR-021-PE) Both are among the few cell-surface-binding antibodies validated for flow cytometry and immune studies. Want to discover why cell surface-specific detection is essential for fl

ALOMONE LABS NEWS From glial activation to synaptic remodeling, here’s what antibody detection actually reveals about neurological disease. Antibody-based protein markers remain a fundamental tool in both research and diagnostics for neurological disorders. But the list of available targets keeps growing – and not all are equally reliable, interpretable, or accessible across sample types. You’ll find examples supported by validated Alomone Labs antibodies, including: Anti-GFA

ALOMONE LABS NEWS NMDA receptors play a central role in learning and memory, and in mice, they are key modulators of fear and its...

ALOMONE LABS NEWS Solute Carrier (SLC) transporters control nutrient flux in cancerous tumors to support growth, stress adaptation, and...

ALOMONE LABS NEWS Science with a Sting When it comes to imaging ion channels, antibodies tend to be large, come with fixation...

ALOMONE LABS NEWS Voltage-gated sodium (NaV) channels are central to sensory signalling – and a growing target for non-opioid pain...

ALOMONE LABS NEWS In this final entry of our cell surface-binding antibody series, we focus on multiplex flow cytometry – and how these...

ALOMONE LABS NEWS In part 4 of our 5-part series, we look at how cell surface-binding antibodies reveal complex biological behaviors in...

ALOMONE LABS NEWS Following NMDA receptor subtypes in live neurons NMDA receptors are crucial for how neurons learn and adapt. They’re...

ALOMONE LABS NEWS What if you could deliver siRNA or silence heat or trigger action potentials in specific neurons using light – no...

ALOMONE NEWS Ion channels aren’t the static entities we often think of them as – they translocate, cluster, internalize, and reset. But...

ALOMONE LABS NEWS Exosomes and other extracellular vesicles (EVs) are everywhere – circulating in biofluids, carrying messages, and...