Are you still thinking about cells in 2D?

Spatial proteomics is both a technical upgrade and a shift in how we understand biology. Imaging mass cytometry (IMC) is revealing that cell identity is deeply tied to spatial context: proximity to vessels, distance from tumor margins, and local immune cell neighborhoods all matter.

In this blog, we explore how antibody markers like p75 and Aquaporin 2, behave in these high-complexity environments, and why antibody selection for IMC demands more than basic specificity. If you're building high-plex panels or interpreting cancer-associated fibroblast (CAF) phenotypes, spatial thinking starts here.

Read full article: https://www.alomone.com/spatial-proteomics-needs-spatial-thinking

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