Cell Surface-Binding Antibodies Part 4: Following Biology in Complex Systems

ALOMONE LABS NEWS

In part 4 of our 5-part series, we look at how cell surface-binding antibodies reveal complex biological behaviors in living systems – from memory encoding in the brain to mechanical transformation in aggressive tumors.

Two standout papers show what’s possible:

In the brain: antibodies against GluN2A and GluN2B NMDA receptor subunits helped track how synapses shift as memories consolidate – and reopen to allow forgetting.

In tumors: antibodies targeting TRPV4, KCNN4 (KCa3.1), and Piezo1 revealed how crowding cues reshape ion channel distribution at the cell surface, triggering a pro-invasive switch in high-grade breast cancer.

Each used antibodies directed against extracellular domains, avoiding fixation artifacts and preserving native protein behavior – exactly what surface-binding antibodies are designed to do.

Discover more https://www.alomone.com/cell-surface-binding-antibodies-part-4-following-biology-in-complex-systems

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