Faster, Better Models for Human Microglia

ALOMONE NEWS

If you're using human induced pluripotent stem cell (hiPSC)-derived microglia to study brain disorders, you know how slow and finicky they can be. A recent study validated a faster route and generated induced microglia (iMGs) from peripheral blood monocytes in under 2 weeks.

These iMGs show the expected morphology, express microglia-specific markers like TMEM119 as well as P2RY12 [detected using Alomone’s Anti-P2Y12 Receptor (extracellular) antibody (#APR-020)], and demonstrate functional activity by engulfing Aβ42. Their gene expression also clusters with brain-resident microglia. That makes them a scalable, immune-relevant model for studying neurodegenerative and neuropsychiatric disorders such as Alzheimer’s disease and schizophrenia.

Making Sure Microglia Are Microglia

Microglial dysfunction contributes to neurological disease. hiPSC-derived microglia model humans but are slow and inconsistent. Newly developed monocyte-derived iMGs show improved immunological, behavioral, and genetic similarity to native microglia

Read more https://www.alomone.com/making-sure-microglia-are-microglia

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