Now Available: ShK-186 Synthetic Peptide and Antibodies Directed Against GPR142 or ADORA3 for Inflammation Research

ALOMONE LABS NEWS

Inflammation sits at the crossroads of metabolism, immunity, and signaling — and these three molecules illustrate how different protein classes converge to shape immune responses.

GPR142, a tryptophan-sensing orphan GPCR primarily known for metabolic regulation, has recently been linked to inflammation. GPR142 is upregulated by proinflammatory cytokines [TNF-α, interleukin (IL)-6, and IL-1β], suggesting a role in amplifying immune or metabolic responses in gut tissues.

Explore: Anti-GPR142 (extracellular)-FITC Antibody (#AGR-082-F)

ShK-186 (dalazatide), a synthetic peptide inhibitor of the Kᵥ1.3 channel, selectively suppresses calcium-dependent activation of effector memory T cells. By blocking Kᵥ1.3, ShK-186 reduces cytokine release [interferon (IFN)γ, TNFα, and IL-17] without broadly suppressing immunity, offering precise control over autoimmune inflammation.

Explore: ShK-186-ATTO Fluor-647N (#STS-390-FRN)

ADORA3, the adenosine A₃ receptor, exerts broad anti-inflammatory effects. ADORA3 activation limits neutrophil degranulation, suppresses cytokine release in macrophages as well as synovial cells, and enhances mucosal protection during gut inflammation.

Explore: Anti-Human Adenosine A3 Receptor (extracellular) Antibody (#AAR-024)

Together, these targets exhibit three complementary strategies of inflammation control — GPR142 as a sensor, ShK-186 as a suppressor, and ADORA3 as a protector — highlighting how GPCR signaling and ion channel modulation converge to fine-tune immune and inflammatory responses.

Per info Contattaci