The Year Membranes Made the Big Decisions

In 2025, some of the most decisive biology happened at the membrane. Receptors, ion channels, and cytoskeletal structures moved beyond signal relay to determine invasion, inflammation, extrusion, and even food choice.

Our new blog recaps some of the year’s most influential papers, including:

Drugging a buried helix to block metastasis

Targeting the p75NTR transmembrane domain shut down NGF-fascin coupling and reduced melanoma lung invasion.

Ion channels steering inflammation and ischemia

BK channel activation limited inflammatory lung injury, while TRPM4/7-linked mechanosensing in pericytes amplified – or restrained – cardiac infarction.

Energy-poor cells flagged for extrusion

In crowded epithelia, ATP-limited cells remained depolarized and activated KV1.1/KV1.2/LRRC8A, triggering their selective removal.

Membrane sensors shaping behavior

TRPA1-dependent gut sensing enforced protein aversion after catabolic stress, while GABAAδ receptors in the gustatory cortex tuned sweet preference under neurosteroid control.

Pharmacology turning correlation into causation

Paired agonists and antagonists targeting membrane proteins – such as BKCa channels, AMPA/kainate receptors, and voltage-gated channels – directly linked membrane signaling to physiological outcomes.

Reagents enabling next-generation measurements

Anti-DAT-FITC, NaV subtype antibodies, and proBDNF standards underpinned advanced cell sorting, spatial profiling, and serum assays, highlighting how reagent quality enables complex biological questions to be answered.

Across oncology, cardiology, metabolism, and neuroscience, a consistent theme emerged: membrane proteins integrated force, energy state, and ligands into outcomes measured in first-tier studies – made visible through carefully validated tools.

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