Why Some Brains Let Go of Fear – and Others Hold On

ALOMONE LABS NEWS

NMDA receptors play a central role in learning and memory, and in mice, they are key modulators of fear and its extinction. In the lateral amygdala, subtle shifts in receptor composition can determine whether fear responses persist — or fade away.

How exactly do these molecular switches shape behavior?

See how our cell surface-binding antibodies:

• Anti-NMDAR2A (GluN2A) (extracellular) Antibody (#AGC-002)

• Anti-NMDAR2B (GluN2B) (extracellular) Antibody (#AGC-003)

• Anti-GluR1 (GluA1) (extracellular) Antibody (#AGC-004)

• Anti-GluR2 (GluA2) (extracellular) Antibody (#AGC-005)

and our Recombinant human Neurotrophin-3 (NT-3) protein (#N-260) helped researchers uncover these mechanisms in Synaptoneurosomes, in a recent paper published in Molecular Psychiatry.

These tools enabled precise detection in Synaptoneurosomes staining, advancing our understanding of how receptor dynamics shape fear and extinction.

Read the full research summary: https://www.alomone.com/nt3-trkc-signaling-suppresses-fear-by-shifting-nmda-receptor-subunits-and-dampening-amygdala-potentiation

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