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Streamline your crystallization workflow with JBScreen Wizard. Systematically designed screening kits combine well-established conditions with innovative formulations to efficiently explore crystallization space - helping you to identify initial hits faster and optimize them with confidence. Discover more Per info Contattaci

Santa Cruz Santa Cruz Biotechnology provides a curated selection of protein modulator chemicals that support researchers across the life sciences. Find a comprehensive portfolio of chemical modulators designed to activate or inhibit protein targets in key research areas, including signal transduction, epigenetics, immunology, & cancer biology. Per info Contattaci

Neurodevelopmental and psychiatric disorders repeatedly converge on synaptic dysfunction. But presynaptic and postsynaptic failures are not interchangeable. Here, we examine two studies that perturb opposite poles of the neurexin-neuroligin adhesion axis: Postsynaptic Neuroligin 2 (NGLN2) C-terminal truncation reduced GABAergic synaptic density and inhibitory transmission, producing obsessive–compulsive disorder (OCD)-like and social deficits in mice. Presynaptic Neurexin 1a

Looking for a faster, easier way to detect RNA? Our Saphir RT-LAMP Kit delivers results in just 15-20 minutes – no thermal cycler needed. Easy to use, highly reliable, and perfect for point-of-care diagnostics, animal health and food safety testing, and many more. Explore rapid RT-LAMP Mix!

Our Protein-Interacting Inhibitors, Activators and Substrates are designed to work seamlessly with our primary antibodies to study protein function. More generalized chemicals such as Prepared Buffers, Surfactants and Solvents are suitable for everyday laboratory use. Per info Contattaci

Cre mRNA is a site-specific recombinase system that enables precise DNA recombination through Cre-LoxP interactions, supporting gene knockout, inversion, and lineage tracing in diverse experimental models. Manufactured via optimized IVT processes, our Cre mRNA incorporates Cap1 structure and a Poly(A) tail to enhance stability and translation efficiency, while modified nucleotides reduce innate immune responses for reliable expression in both in vitro and in vivo applications

Capillaries regulate much of the brain’s vascular resistance, yet the molecular signals controlling pericyte contractility remain poorly defined. A recent study showed that Pannexin 1 (Panx) channels expressed in pericytes regulate capillary diameter by controlling ATP release and purinergic signaling. In the mouse hippocampus, Panx1 activity amplified pericyte Ca²⁺ signaling, drove ATP-dependent capillary constriction, and mediated glutamate-evoked dilation during neuronal a

GLUT1 controls antibody quality and T cell effector function, and glucose transport is much more than just a background metabolic process in adaptive immunity. Two recent papers demonstrated that GLUT1-mediated glucose influx : Sustains germinal center B cell expansion and plasma cell (PC) differentiation Determines the ATP:ADP ratio and IFN-γ output in effector T cells Links nutrient availability to immune function across space and time In both cases, surface GLUT1 expressi

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Tumors are mechanically abnormal systems. They are crowded, stiff, and force transmitting. But how those forces become specific cancer phenotypes has remained unclear. Here we look at three recent studies in breast, pancreatic, and bladder cancer that converge on shared principles: TRPV4 functions as a mechanotransduction node – but its biological impact depends on mechanical regime and cell type. In crowded breast ductal carcinoma in situ (DCIS), reduced TRPV4 activity perm

In science, access to publications is crucial for selecting products for a specific application. Bioz’ technology provides real-time access to the latest product citations in scientific literature to help you establish your assay of interest. Learn how it works!

PAN-Biotech is pleased to present our new product catalog , which contains a comprehensive portfolio of high-quality products for modern cell culture and life science applications . It includes our range of premium sera , classic and specialized media , GMP grade products , and a broad selection of reagents , buffer , antibiotics , and water  designed to support reliable and reproducible workflows. Check the catalogue: https://pan-biotech.com/wp-content/uploads/PAN-Biotech

Astrocyte reactivity is a hallmark of neurological disease, but reactivity alone doesn’t explain outcome. Two recent studies take a causal approach, isolating astrocyte-specific GPCR pathways and testing their direct effects on neuronal circuits. One pathway pushes networks toward hyperexcitability through P2Y1R/IGFBP2 signaling. The other pulls circuits back toward homeostasis via GPR37L1/GLT-1-dependent glutamate clearance. Together, the data argue for a push–pull model of

Neuro-immune communication has long been treated as a background condition: inflammation here, neural activity there. Two recent mouse studies alter our understanding of neuro-immune crosstalk. Together, they show that peripheral cells can influence and actively decide outcomes. Platelets tune hippocampal inhibition by setting serotonin availability. Sensory neurons direct humoral immunity through stimulus-dependent neuropeptide release. The common thread is that transporters

Discover a stepwise protocol for 5-EdU incorporation and subsequent DNA synthesis detection via Copper-catalyzed Click Chemistry in Zebrafish. Read more...

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In our Featured Article series, we regularly highlight a recently published scientific paper. "Ligand specific activation trajectories dictate GPCR signaling in cells" - by Thomas et al. (Nature, Jan 14, 2026) is our latest featured scientific article. Read the full story!

A new Nature Aging study reports that only a fraction of aged HSCs preserves long-term regenerative capacity, and they can be identified by high mitochondrial mass. These mito-Dendra2 High HSCs generated more donor-derived long-term HSCs 16 weeks after transplantation than their mito-Dendra2 Low counterparts, despite producing similar peripheral blood output. Single-cell transcriptomics showed that this subset maintains elevated autophagy, mitophagy, iron handling, and mito

JENA NEWS Need a selection antibiotic for your organism? Nourseothricin can be used for selection of over 100 different species from all kingdoms of life – at affordable costs! Learn more...

Spatial proteomics is both a technical upgrade and a shift in how we understand biology. Imaging mass cytometry (IMC) is revealing that cell identity is deeply tied to spatial context: proximity to vessels, distance from tumor margins, and local immune cell neighborhoods all matter. In this blog, we explore how antibody markers like p75 and Aquaporin 2, behave in these high-complexity environments, and why antibody selection for IMC demands more than basic specificity. If yo